abstract：:Nitric oxide (NO) is a messenger molecule that mediates several physiological functions and pathological processes. Sodium nitroprusside (SNP), a potent vasodilator, when given clinically as an anti-hypertension agent, exerts its function by releasing NO. It was reported recently that SNP causes a loss of auditory ner...

journal_title：Hearing research

authors： Kong WJ,Ren T,Nuttall AL

更新日期：1996-09-15 00:00:00

abstract：:Guinea pigs were exposed to pure tones of 10 kHz at intensities between 98 and 115 dB SPL for 5-30 min, to produce varying degrees of acoustic trauma. Changes in auditory thresholds were measured electrophysiologically, and the animals were immediately fixed for scanning electron microscopy. Correlation between morpho...

journal_title：Hearing research

authors： Clark JA,Pickles JO

更新日期：1996-09-15 00:00:00

abstract：:Distortion product otoacoustic emission (DPOAE) iso-suppression tuning curves (STC) were generated in 15 normal-hearing adults and 16 healthy term-born neonates for three f2 frequencies. The 2f1-f2 DPOAE was elicited using f2/f1 = 1.2, LI = 1.2, LI = 65 and L2 = 50 dB SPL. A suppressor tone was presented at frequencie...

journal_title：Hearing research

authors： Abdala C,Sininger YS,Ekelid M,Zeng FG

更新日期：1996-09-01 00:00:00

abstract：:Frequency and impulse responses were determined for isolated guinea pig outer hair cells by electrically stimulating the cells between two wire electrodes with white noise. Cells were attached to the bottom of a small culture dish at one end while the other end was freely moving. Results have the character of a damped...

journal_title：Hearing research

authors： Wit HP,van Dijk P,Segenhout HM

更新日期：1996-09-01 00:00:00

abstract：:The distribution of calcitonin gene-related peptide immunoreactivity (CGRPi) within efferent vestibular neurons in the chinchilla was investigated using fluorescent retrograde labeling combined with immunohistochemistry. Efferent vestibular neurons were found bilaterally in clusters: dorsolateral (group E1) and medial...

journal_title：Hearing research

authors： Marco RA,Hoffman LF,Wackym PA,Micevych PE,Popper P

更新日期：1996-08-01 00:00:00

abstract：:Two-tone suppression was studied in the auditory nerve fibers of anesthetized cats, using low-frequency suppressors (50-2000 Hz). The response to the characteristic-frequency (CF) tone was suppressed in a phase-specific manner, attaining one or two minimums in 1 cycle of the suppressor (SUP) tone. The suppression phas...

journal_title：Hearing research

authors： Cai Y,Geisler CD

更新日期：1996-07-01 00:00:00

abstract：:The acoustic distortion product 2f1-f2 was measured in the ear canal of the gray short-tailed opossum. Monodelphis domestica, during stimulation with two pure tone stimuli of the frequencies f1 and f2 (f1 < f2). From 2f1-2f growth functions for different primary frequencies from 4 to 85 kHz, a distortion threshold cur...

journal_title：Hearing research

authors： Faulstich M,Kössl M,Reimer K

更新日期：1996-05-01 00:00:00

abstract：:Gerbils are frequently used in auditory research; however, only limited information on the exact frequency representation in the cochlea is available. Therefore the place-frequency map of the gerbil was determined by iontophoretic application of horseradish peroxidase in physiologically characterized single auditory n...

journal_title：Hearing research

authors： Müller M

更新日期：1996-05-01 00:00:00

abstract：:Little is known about inner ear development in pigeons. This paper addresses the question of maturation in activity patterns of pigeon auditory nerve fibres, Pigeons that were 1, 2 and 4 weeks and 1, 2, 3 and 4 years old were investigated. Adult-like activity patterns are found 4 weeks post-hatching. Spontaneous activ...

journal_title：Hearing research

authors： Richter CP,Sauer G,Hoidis S,Klinke R

更新日期：1996-05-01 00:00:00

abstract：:An analysis of the central projections of the ventral nucleus of the trapezoid body (VNTB) in the rat, a region of the superior olivary complex known for its neuronal heterogeneity, was made using two anterograde axonal tracers, [3H]leucine and biotinylated dextran amine (BDA). A mixture of these tracers was injected ...

journal_title：Hearing research

authors： Warr WB,Beck JE

更新日期：1996-04-01 00:00:00

abstract：:Electrical stimulation of the cochlea is known to cause auditory sensations in humans and other animals. It also has been shown to produce emissions of sound from the inner ear. In the current study we investigate the relationship between electrically induced motion of the basilar membrane (BM) and the production of o...

journal_title：Hearing research

authors： Nuttall AL,Ren T

更新日期：1995-12-01 00:00:00

abstract：:In this study 9 human temporal bones from 8 individuals were fixed with Karnovsky solution by perilymphatic perfusion within 1-3 h after death and examined using the "block-surface method' (Spoendlin and Brun, 1974; Spoendlin and Schrott, 1987) and the "micro-dissection method' (Johnsson and Hawkins, 1967). The audiog...

journal_title：Hearing research

authors： Felder E,Schrott-Fischer A

更新日期：1995-11-01 00:00:00

abstract：:A simple model for the acoustic enhancement of electrically evoked otoacoustic emissions (EEOEs) is presented in this paper. The model is based on the assumption that the enhancement is a result of the local interaction between the electrical current spreading in the scala media and the basilar membrane (BM) response ...

journal_title：Hearing research

authors： Xue S,Mountain DC,Hubbard AE

更新日期：1995-11-01 00:00:00

abstract：:Auditory-nerve excitation by two response factors that can be in antiphase has been hypothesized by Kiang (1990) on the basis of non-linear interference in responses to tones (Kiang et al., 1969). The general conditions for antiphasic responses and the relevance of the hypothesis for other auditory stimuli are unknown...

journal_title：Hearing research

authors： Lin T,Goldstein JL

更新日期：1995-10-01 00:00:00

abstract：:The goal of the present paper is to relate the coding of amplitude modulation (AM) in the auditory pathway to the behavioral detection performance. To address this issue, the detectability of AM was estimated by modelling a single neuron located in the central nucleus of the inferior colliculus (IC). The computational...

journal_title：Hearing research

authors： Lorenzi C,Micheyl C,Berthommier F

更新日期：1995-10-01 00:00:00

abstract：:There is accumulating evidence for a purinergic humoral system involved in the control of cochlear function. Evidence of specific P2 purinoceptors on cochlear tissues implies a role for extracellular adenosine triphosphate (ATP) in the cochlea. To further this hypothesis a study was undertaken to determine if there wa...

journal_title：Hearing research

authors： White PN,Thorne PR,Housley GD,Mockett B,Billett TE,Burnstock G

更新日期：1995-10-01 00:00:00

abstract：:Behavioral studies on complex sound perception in goldfish were carried out in order to help determine what, if any, differences exist between the sense of hearing of fishes and other vertebrates. A stimulus generalization paradigm was used with classical conditioning in three experiments to determine: (1) the percept...

journal_title：Hearing research

authors： Fay RR

更新日期：1995-09-01 00:00:00

abstract：:High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium....

journal_title：Hearing research

authors： Chen L,Trautwein PG,Miller K,Salvi RJ

更新日期：1995-09-01 00:00:00

abstract：:The effects of genotype and diet on age-related hearing loss were evaluated using auditory brainstem response (ABR) thresholds and post-mortem cochlear histopathology in 5 inbred mouse strains, CBA/H-T6J (CH), DBA/2J (D2), C57BL/6J (B6), BALB/cByJ (BY) and WB/ReJ (WB), and their 10 F1 hybrid strains. The mice had been...

journal_title：Hearing research

authors： Willott JF,Erway LC,Archer JR,Harrison DE

更新日期：1995-08-01 00:00:00

abstract：:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP t...

journal_title：Hearing research

authors： van Emst MG,Klis SF,Smoorenburg GF

更新日期：1995-08-01 00:00:00

abstract：:We recorded auditory evoked magnetic fields from 8 patients with unilateral, idiopathic, sudden, sensorineural hearing loss and from 8 healthy controls, using a 122-channel whole-scalp neuromagnetometer. The stimuli were 50-ms l-kHz tone bursts, delivered to the healthy ear at interstimulus intervals (ISIs) of 1, 2, 4...

journal_title：Hearing research

authors： Vasama JP,Mäkelä JP

更新日期：1995-07-01 00:00:00

abstract：:Carbohydrate distribution in the fresh utricular macula of the guinea pig was analysed using lectins such as Concanavalin A (ConA), Dolichos biflorus agglutinin (DBA), peanut agglutinin (PNA), soybean agglutinin (SBA), Ulex europeus agglutinin (UEA-1) and wheat germ agglutinin (WGA) by means of confocal laser scanning...

journal_title：Hearing research

authors： Suzuki H,Katori Y,Ikeda K,Takasaka T

更新日期：1995-07-01 00:00:00

abstract：:A linear (frequency-domain) model of the cat cochlea (implemented in both 1- and 2-dimensional versions) has been developed which uses outer hair cell (OHC) forces in a geometry which includes the longitudinal (base-to-apex) tilt of the outer hair cells (OHCs). When positive (contractile) real OHC force-constants are ...

journal_title：Hearing research

authors： Geisler CD,Sang C

更新日期：1995-06-01 00:00:00

abstract：:A novel immunocytochemical method was used to determine whether the sound-damaged adult quail ear can repair its tectorial membrane (TM) and to compare the repair in quail to that in chicks. Birds were exposed to an octave band noise with a center frequency of 1.5 kHz at 116 dB SPL for 4 h. The chicks were grouped bas...

journal_title：Hearing research

authors： Adler HJ,Niemiec AJ,Moody DB,Raphael Y

更新日期：1995-06-01 00:00:00

abstract：:The f2-f1 distortion product otoacoustic emission (DPOAE) can be observed to undergo gradual alterations in amplitude during continuous ipsilateral stimulation with primary tones. In the present experiments, we characterized the dependence of these amplitude alterations on several stimulus variables (intensity, durati...

journal_title：Hearing research

authors： Kujawa SG,Fallon M,Bobbin RP

更新日期：1995-05-01 00:00:00

abstract：:The scalp distributions of middle latency auditory evoked potentials (MAEPs) elicited by tone bursts of 250 and 4000 Hz were compared in two experiments. Na (19.9 ms), Pa (29.8 ms), and Pb (51.4 ms) components elicited by tones of either frequency had fronto-central distributions, whereas the Nb component (38.4 ms) wa...

journal_title：Hearing research

authors： Woods DL,Alain C,Covarrubias D,Zaidel O

更新日期：1995-05-01 00:00:00

abstract：:Two different radioligands were used to identify extracellular ATP binding sites specific to P2 purinoceptors in guinea-pig cochlear tissue. Deoxyadenosine 5'-(alpha-[35S]thio)triphosphate ([35S]dATP alpha S; 10 nM) provided a high activity probe for the P2y purinoceptor subtype on the basis of selective block by 2-me...

journal_title：Hearing research

authors： Mockett BG,Bo X,Housley GD,Thorne PR,Burnstock G

更新日期：1995-04-01 00:00:00

abstract：:Sound-induced displacement responses in the plane of the organ of Corti were studied in the apical turn in the isolated temporal-bone preparation of the guinea-pig cochlea. Swept sinusoidal sound stimuli (100-500 Hz) were delivered closed-field to the external auditory meatus. The surface of the organ of Corti was con...

journal_title：Hearing research

authors： Morioka I,Reuter G,Reiss P,Gummer AW,Hemmert W,Zenner HP

更新日期：1995-03-01 00:00:00

abstract：:Alterations in the distribution and activity of Na,K-ATPase have been implicated in declining cell function with age. However, the location, size and anatomical complexity of the cochlea have limited study of this essential enzyme. Here we describe a micro-colorimetric assay which measures Na,K-ATPase activity in subr...

journal_title：Hearing research

authors： Gratton MA,Smyth BJ,Schulte BA,Vincent DA Jr

更新日期：1995-03-01 00:00:00

abstract：:Primary afferent activity was recorded from the cochlear ganglion in chicken embryos (Gallus domesticus) at 19 days of incubation (E19). The ganglion was accessed via the recessus scala tympani and impaled with glass micropipettes. Frequency tuning curves were obtained using a computerized threshold tracking procedure...

journal_title：Hearing research

authors： Jones SM,Jones TA

更新日期：1995-02-01 00:00:00

abstract：:The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...

journal_title：Hearing research

authors： Aitkin L

更新日期：1995-02-01 00:00:00

abstract：:The lipophilic dye, DiI, was placed into the macula lagena of paraformaldehyde-fixed embryonic chicks. Retrogradely labeled cells were found bilaterally in the pontine reticular formation (RF) between the dorsal facial nucleus and the abducens nerve root. This location is similar to that of the dorsomedial group of ef...

journal_title：Hearing research

authors： Code RA

更新日期：1995-01-01 00:00:00

abstract：:A cochlear frequency-place map was developed for adult chickens by labeling cochlear ganglion neurons with biocytin and correlating the location of each labeled fiber along the basilar papilla with the characteristic frequency of the unit's tuning curve. Labeled fibers showed little or no branching within the sensory ...

journal_title：Hearing research

authors： Chen L,Salvi R,Shero M

更新日期：1994-12-01 00:00:00

abstract：:Spongiform lesions of the gerbil cochlear nucleus are reduced in number and extent by rearing in acoustic isolation compared with rearing while exposed to normal colony low-frequency background noise. This study tested whether rearing under exposure to noise bands of moderate intensity would increase the number and ex...

journal_title：Hearing research

authors： McGinn MD,Faddis BT

更新日期：1994-12-01 00:00:00

abstract：:Validity of the neurophysiological model of tinnitus (Jastreboff, 1990), outlined in this paper, was tested on data from multicenter trial of tinnitus masking (Hazell et al., 1985). Minimal masking level, intensity match of tinnitus, and the threshold of hearing have been evaluated on a total of 382 patients before an...

journal_title：Hearing research

authors： Jastreboff PJ,Hazell JW,Graham RL

更新日期：1994-11-01 00:00:00

abstract：:Most previous reports of ototoxicity following exposure to several volatile organic solvents have restricted testing to the low- and mid-frequencies (2-20 kHz) of the hearing range in the rat (0.25-80 kHz). We report here that inhalation exposure to styrene, mixed xylene, toluene, and 1,1,2-trichloroethylene resulted ...

journal_title：Hearing research

authors： Crofton KM,Lassiter TL,Rebert CS

更新日期：1994-10-01 00:00:00

abstract：:The presence of dopamine (DA) within the cochlea has been previously reported, indicating that its turnover increases under noise stimulation. In the present report, piribedil, a dopaminergic D2 agonist, was used in order to provide evidence of the activity of D2 receptors in the turnover of DA under noise stimulation...

journal_title：Hearing research

authors： Gil-Loyzaga P,Vicente-Torres MA,Fernández-Mateos P,Arce A,Esquifino A

更新日期：1994-09-01 00:00:00

abstract：:Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned int...

journal_title：Hearing research

authors： Furuta H,Mori N,Sato C,Hoshikawa H,Sakai S,Iwakura S,Doi K

更新日期：1994-08-01 00:00:00

abstract：:With the purpose of pinpointing the time of onset of electromotility, outer hair cells (OHCs) from apical and basal turns of the cochleae of postnatal gerbils, ranging in age from 6 to 19 days, were isolated and drawn into a glass microchamber. Length changes evoked by transcellular electrical stimulation were detecte...

journal_title：Hearing research

authors： He DZ,Evans BN,Dallos P

更新日期：1994-07-01 00:00:00

abstract：:Cochlear function was monitored in adult gerbils using distortion product otoacoustic emissions (DPOAE) during intraperitoneal injection of furosemide. All stimulus parameters were varied independently over a wide range, the stimulus frequencies f1 and f2 from 1 to 16 kHz, and the stimulus levels L1 and L2 from 20 to ...

journal_title：Hearing research

authors： Mills DM,Rubel EW

更新日期：1994-06-15 00:00:00